Following a tradition that can be traced at least from Descartes to Heidegger, western philosophy has assumed the subject-object duality questioning constantly the interactions and characteristics of both notions. Can the subject access reality? Descartes conceptualized the mind (the thinking “I”) as fundamentally distinct from external reality. Heidegger, in a revolutionary approach, takes the being of the subject (Dasein) to be intimately intertwined with the world—however, he still preserves a meaningful, if more fluid, distinction between Dasein (the subject) and the objects it encounters. On the other hand, Buddhist philosophers have taken a more radical approach. Ratnakīrti’s emphasis on the mind’s conceptual constructs and Nāgārjuna’s insistence that nothing has an independent essence both challenge the classical subject–object duality even questioning the existence of reality. This paper dissects Ratnakīrti’s and Nāgārjuna’s arguments to challenge the notion that our mind can access truth.