Interpretations of synesthesia—the linking of discrete sensory and cognitive pathways—range from mental disorder to rare artistic gift. A mainstay of poetic description for centuries, the phenomenon has nevertheless eluded definitive explanation by scientists. This project explores the significance of synesthesia and color perception in merging literature, science, and mysticism within the literary essays of Aldous Huxley. Specifically, I trace Huxley's shifting views on the relationships between color and meaning from "The Art of Seeing" (1942) to his later essays on psychedelic self-experimentation, "The Doors of Perception" (1954) and "Heaven and Hell" (1956). In situating his literary-philosophical articulations of color within contemporary scientific research on synesthesia and sense perception, I explore Huxley's attempts to heal the rifts between literary and scientific ways of knowing.